The Schuettpelz lab studies how inflammation regulates hematopoietic stem cells (HSCs) and contributes to the development of hematopoietic malignancies. Inflammatory signals are important for the normal development of the immune system and the response to acute infection or injury, however sustained inflammatory signaling can impair HSC function. Furthermore, inflammatory signals can promote the clonal expansion of mutant HSCs and the development of hematopoietic malignancies. Understanding how both normal and mutant HSCs respond to inflammation is important for identifying strategies to optimize HSCs function and prevent blood cancers.

Learn more about our research …

Laura Schuettpelz spotlight photo

Principal Investigator

Laura G. Schuettpelz, MD, PhD

Laura Schuettpelz was born and raised in Boulder, Colorado. After graduating from Creighton University, she completed a PhD in molecular biology from Northwestern University. With a desire to combine her passion for science and an interest in clinical medicine, she then pursued an MD at Northwestern University as well.

Schuettpelz came to Washington University in 2005 for her pediatrics residency and fellowship in pediatric hematology/oncology. She completed her postdoctoral work with Daniel Link, MD in 2013 and opened her own laboratory at Washington University.

Work in our laboratory is supported by…

National Institutes of Health (NHLBI)

Alex’s Lemonade Stand Foundation

Child Health Research Center at Washington University

The Children’s Discovery Institute

Hyundai Hope on Wheels